PT-141 (Bremelanotide) – Melanocortin Receptor Research Peptide
Compound Name: Bremelanotide (PT-141)
Classification: Research Peptide – Melanocortin Receptor Agonist
Description:
PT-141 is a synthetic research peptide derived from the melanocortin family and is
structurally related to alpha-melanocyte–stimulating hormone (α-MSH). In controlled
laboratory research environments, PT-141 is widely studied for its interactions with
melanocortin receptors, particularly MC3R and MC4R, which are involved in peptide-mediated
signaling and regulatory pathways.
Researchers utilize PT-141 in in-vitro and biochemical model systems to investigate
melanocortin receptor activation, intracellular signaling cascades, and peptide–receptor
binding dynamics. Due to its receptor specificity and signaling profile, PT-141 serves as
a valuable research compound for studying melanocortin-regulated biological processes and
neuroendocrine signaling models.
This compound is supplied in lyophilized (freeze-dried) powder form to enhance
stability for controlled laboratory research applications.
References:
- Dhillon S, Keam SJ.
Bremelanotide: First Approval.
Drugs. 2019;79(14):1599–1606.
PMID: 31429064 - Diamond LE, Earle DC, Garcia WD, Spana C.
Co-administration of low doses of intranasal PT-141 and sildenafil results in enhanced erectile response.
Urology. 2005;65(4):755–759.
PMID: 15833522 - Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB.
Evaluation of the safety and pharmacodynamic effects of PT-141 in male subjects.
Int J Impot Res. 2004;16(2):135–142.
PMID: 14999221
Disclaimer:
For Laboratory Research Use Only (RUO).
Not for human consumption. Not for therapeutic, diagnostic, or veterinary use.
